High-Calories regimen in pregnancy probably promote breast cancer danger

Through a gene screen, researchers found several genes in women linked to increased breast Cancer risk, increased resistance to cancer treatment, poor cancer prognosis and impaired anti-cancer immunity. July 3 (UPI) -- A recent study with mice at Georgetown University shows a high-fat diet during pregnancy can increase the risk of breast cancer over generations. The research found that eating a high-fat diet before and during pregnancy increased the risk of breast cancer in subsequent generations but did not cause inheritable changes in the germ cells. "Of the 1.7 million new cases of breast cancer diagnosed in 2012, 90 percent have no known causes. The study, published July 3 in Breast Cancer Research, revealed a number of genetic changes in the first and third generation females in mice that were fed high-fat diets during pregnancy.




By comparison, eating a high-fat diet before and during pregnancy increase breast cancer risk in the subsequent two generations, but does not cause inheritable changes in the germ cells, Hilakivi-Clarke says. "Of the 1.7 million new cases of breast cancer diagnosed in 2012, 90 percent have no known causes," she says. "The soil in the breast, so to speak, remained fertile for breast cancer development in our high-fat experimental mice," Hilakivi-Clarke says. A high-fat diet is linked to excess inflammation, and a number of epidemiological studies have made the connection between inflammation and risk of cancer, she says. The researchers also found three times as many genetic changes in third generation than first generation mammary tissue between high-fat diet progeny and the control group's offspring.

High-Calories regimen in pregnancy probably promote breast cancer danger: research

(AFP PHOTO/YASUYOSHI CHIBA)WASHINGTON, July 3 (Xinhua) -- High-fat diet in pregnancy may increase the risk of breast Cancer over generations, a new mice study suggested Monday. "Of the 1.7 million new cases of breast cancer diagnosed in 2012, 90 percent have no known causes," she said. "Studies have shown that pregnant women consume more fats than non-pregnant women, and the increase takes place between the first and second trimester," Hilakivi-Clarke said. Feeding pregnant female mice a diet high in fat derived from common corn oil resulted in genetic changes that substantially increased the susceptibility of breast cancer in three generations of female offspring, according to the study published online in the journal Breast Cancer Research. The new study revealed a number of genetic changes in the first and third female generations of mice that were fed high-fat diets during pregnancy, including several genes linked in women to increased breast cancer risk, increased resistance to cancer treatment, poor cancer prognosis and impaired anti-cancer immunity.


collected by :Lucy William